The research and development racing to extend the human lifespan, explained in plain English: the new studies, the treatments being tested, and what experts say about them.
Read every morning from PubMed · ClinicalTrials.gov · bioRxiv · medRxiv · FDA
Extends lifespan in mice. Human studies so far are small.
Picked from each morning's update, with this morning's finds first: studies in people, popular treatments, big trials and FDA news.
The clearest step today is a vaccine that trains the immune system to clear old, worn-out cells, which in aged mice improved blood sugar and liver fat and raised median lifespan by 12%, though the study was small. A second report found the same kind of vaccine improved metabolism and extended lifespan in several mouse models. Separately, restoring a fat in muscle energy factories reversed some muscle wasting in mice, with a link to aging also seen in human muscle samples. All of this is early, animal-based work.
Researchers in China made a vaccine that trains the immune system to find and clear old, worn-out cells that have stopped dividing and give off harmful signals, which build up with age. In mice, it lowered signs of these cells in fat, improved blood sugar handling and liver fat, and in naturally aged mice vaccinated at 75 weeks it raised median lifespan by 12% compared with untreated mice. This was only in mice, with 10 per group, and the comparison mice were relatively short-lived, so it is an early proof of concept that needs more rigorous studies.
The everyday basics: habits, check-ups, everyday supplements and home health devices, with how far the research on each has got and which ones major health guidelines recommend.
What people are experimenting with to live longer, placed by how far testing in people has gone. A stage shows how much research there is, not whether something will work for you. Select one for details.
Extends lifespan in mice. Human studies so far are small.
Stage 2 because 25 published trials and 40 registered trials in people have been found, but no large ones yet.
Stages are worked out automatically from PubMed, ClinicalTrials.gov and FDA records every morning. They show how far research has got, not how well something works. Companies cannot pay to change them. How stages work · All treatments
Stages are worked out automatically from the research records every morning. They show how far research has got, not how well something works. How stages work
Peptides are short chains of amino acids, the building blocks of proteins, and the body uses many of them as messengers. A few lab-made peptides are approved drugs, such as semaglutide (Wegovy). Many others are sold online without approval, with little or no testing in people.
What's changing · October 30, 2026HHS published a draft policy: it won't act against pharmacies that make BPC-157 and five other peptides under set conditions. It isn't an FDA approval.What it means →Stages come from PubMed and ClinicalTrials.gov, and FDA status from the FDA's own pages. We don't sell peptides, give doses or recommend any.
Pick what matters to you. Each guide shows what people try, how far the research on each has got, and the products and tests that go with it.
Look youngerFace and skin · Hair · Body · Clinic treatments25 options compared →
Stay strong and mobileMuscle · Bones and joints · Balance and mobility16 options compared →Protect your brain and memoryMemory and focus · Mood · Sleep18 options compared →
Heart and blood pressureBlood pressure · Cholesterol · Blood sugar34 options compared →
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These tests estimate how old your body seems, or how fast it is aging, from a finger prick, a cheek swab or a blood draw. People use them to see where they are starting from and to track changes over time.
Results are estimates. The science behind them is still settling, and two tests can give the same person different numbers.
Chemical tags on your DNA shift as you age. A clock reads thousands of them and estimates a biological age.
What the research shows so farStrong for large groups of people. Less certain for one person tracked over time.
6 papers on TruAge in PubMed →Sugar chains attached to your antibodies change with age and inflammation. A newer approach with a smaller research base.
What the research shows so farPromising research, with fewer independent studies so far.
6 papers on GlycanAge in PubMed →Standard lab measures like blood sugar, cholesterol and inflammation, sometimes combined into an age score.
What the research shows so farEach marker is well studied. Combined age scores are less so.
The supplements people ask about most, for longevity and for everyday health. For each: how far the research has got, what studies found, and what makers sell. Forms and doses are copied from each label; we don't rank products.
Taken forA molecule the body uses to make NAD+, which cells need to turn food into energy.
A review of studies found that effects of NMN and a related compound on health outcomes were mixed and often null.
Taken forA compound gut bacteria make from foods such as pomegranates, berries and walnuts. It is studied for how cells clear out worn-out energy parts.
A review of studies found urolithin A raised some mitochondrial genes, signs of autophagy, and fatty acid burning. Mitochondria are the cell's energy makers.
Taken forNR (nicotinamide riboside) is a compound that can raise levels of NAD+, a molecule in the body that declines with age.
A review of studies found that oral NR raised NAD-related substances in blood or cells in humans.
Taken forA plant compound found in strawberries and apples.
The review's results imply a positive outlook for fisetin and the other substances as a possible Alzheimer's treatment.
Taken forBerberine is a substance found in several plants, such as goldenseal, barberry, and Oregon grape.
There is some evidence that berberine may modestly lower blood sugar in people with type 2 diabetes and may reduce cholesterol.
Taken forCreatine supplements can increase strength, power, and the ability to contract muscles for maximum effort.
Taken forA prescription shot of B12 is usually used to treat vitamin B12 deficiency.
The fact sheet says B12 does not give energy or endurance benefits in people who get enough from their diet.
Taken forCalcium is a mineral your body needs to build and maintain strong bones and to carry out many important functions.
Some studies found calcium supplements raise bone density in older adults, but others did not.
Taken forSome people take a multivitamin as a form of dietary or nutritional insurance.
A few studies found older people who took a multivitamin for 1 to 3 years had better thinking and memory.
Taken forPsyllium is used to treat constipation.
Taken forMagnesium is also included in some laxatives and in some products for heartburn and indigestion.
A review of studies found that magnesium supplements lowered diastolic blood pressure (the bottom number) by only a small amount.
7 ideas scientists are testing, each shown by the research stages its treatments have reached so far, from studies in animals to approval or a major guideline.
Each lit step shows how many of the idea's treatments have reached that stage. A stage is for a treatment's main use on this site: stage 4 means approved or recommended for something, not for reversing aging. New studies are sorted into these ideas automatically every morning.
Every aging-related trial that is recruiting, explained in plain words: what is tested, who can join, and where.
Everything we read each morning, with the original papers, trial records and the exact searches behind every number.
Services, prices and places are copied from each clinic's own site, word for word, and dated. We don't rate clinics, and a paid listing never changes what we show.
61 clinics in 16 countries, with what each says it offers and charges.
First Visit “30-minutes. We'll dig into your symptoms, health history, and goals, then build a care plan tailored to you.”Clinic site ↗
Single injection or aesthetic-only treatment “This life-improving therapy involves a significant personal investment , one that reflects 100M+ fresh, verified cells with 99% viability , processed in-house with complete chain-of-custody standards.”Clinic site ↗
Advanced Detox “Our signature Chenot programme aims to induce a deep purification and detoxification of the body to eliminate toxins, increase vitality, reset energy levels and rebalance its physiology.”Clinic site ↗
Talks and interviews from aging research institutes, scientific meetings and longevity companies, picked up every morning. Each one is shown beside how far the research on what it covers has really got.
The popular books on aging, and how far the research on what they discuss has got.
The week's most useful new research on aging, explained for everyday readers. Sent Sundays at 7 AM ET.
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